Steroids efficacy in the acute management of seizure clusters in one case of PCDH19 female epilepsy
نویسندگان
چکیده
We read with great interest the paper entitled ‘‘Immediate suppression of seizure clusters by corticosteroids in PCDH19 female epilepsy’’ by Higurashi et al. [1]. Clusters of febrile and afebrile seizures, mainly focal motor or hypomotor with affective symptoms, are typical of PCDH19 female epilepsy (PCDH19-FE) [2]. After first reporting on the excellent efficacy of corticosteroids in acute cluster termination in one
منابع مشابه
Immediate suppression of seizure clusters by corticosteroids in PCDH19 female epilepsy
PURPOSE The pathomechanism and treatment of PCDH19 female epilepsy (PCDH19-FE) remain unclear. Here, we report that corticosteroids are effective for control of the seizure clusters or other acute symptoms of PCDH19-FE and argue for the possible involvement of a compromised blood-brain barrier (BBB) in its pathogenesis. METHODS The efficacy of corticosteroids was retrospectively reviewed in f...
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PURPOSE Mutations in PCDH19, encoding protocadherin 19 on chromosome X, cause familial epilepsy and mental retardation limited to females or Dravet-like syndrome. We wished to explore the causative role of PCDH19 gene (Xq22) in female patients with epilepsy, from Southern Italy. METHODS Direct sequencing of PCDH19 gene was conducted in 31 unrelated female patients with early onset (<1 year of...
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Background and Objectives: Epilepsy is a chronic condition results in seizure and leads to debilitating conditions in patients. Epilepsy self-management behaviors include activities to manage the disease. The aim of this study was to assess self-management behaviors and its correlation with seizure frequency in patients with epilepsy. Materials and Methods: In this correlation study, 120 patien...
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OBJECTIVE To explore the causative role of PCDH19 gene (Xq22) in female patients with epilepsy. METHODS We studied a cohort of 117 female patients with febrile seizures (FS) and a wide spectrum of epilepsy phenotypes including focal and generalized forms with either sporadic or familial distribution. RESULTS PCDH19 screening showed point mutations in 13 probands (11%). Mean age at seizure o...
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عنوان ژورنال:
- Seizure
دوره 32 شماره
صفحات -
تاریخ انتشار 2015